Endocrine Abstracts

The Glucagon-like peptide-1 (GLP-1) receptor is expressed in the lung having a very important role in the modulation of the Angiotensin Converting Enzymes (ACEs). ACE1 cleaves angiotensin-I into angiotensin-II, which is converted by ACE2 to Ang(1-7). Ang(1-7) has vasodilating effects. The Idiopathic Pulmonary Fibrosis (IPF) is characterized by excessive extracellular matrix deposition disrupting the alveolar architecture and physiology. IPF develops by a sequence of inflammati...

The Glucagon-like peptide-1 receptor is widely expressed in diverse tissues including the liver. GLP-1 contributes itself to the regulation of glucose homeostasis and has important effects in lipid metabolism even preventing liver steatosis induced by high fat diets.The aim of this study was to analyse the short-term effects of liraglutide on key enzymes of the hepatic energy metabolism.Thirty-six Sprague-Dawley young adult male ra...

Adverse events during gestation in rodents, results in an enhancement of immune function, including elevated levels of inflammatory cytokines in the brain. Liraglutide is a GLP-1 receptor agonists known to exert neuroprotective effects in brain. The aim of this study was to elucidate if liraglutide given to food restricted (FR) pregnant rats may prevent the deleterious effects of FR in the hippocampal inflammatory status of male and female pups at 21 days of age (D21). 20 Spra...

Introduction: First described in 2009, IgG4-related thyroid disease includes several subcategories: Riedel’s thyroiditis, fibrous variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis (HT) and Graves’ disease with elevated IgG4. It is rare, with most cases described in Japan and characterized by increased IgG4 plasma cells at immunostaining.Case Report: A 59-year-old Caucasian women, without known Asian ancestry, was obser...

Acute lung injury (ALI) is characterized by endothelial and epithelial damage, followed by inflammatory. Glucagon-like peptide-1 (GLP-1) is a gut-produced hormone with insulinotropic effects. GLP-1 receptor is expressed in the lung, and there implicated in the synthesis of surfactant proteins. We have previously shown that liraglutide (LIR), a GLP-1 receptor agonist, restores surfactant protein-B (SPB) levels, a limiting factor for survival, and also angiotensin converting enz...

Food restriction (FR) of mothers during the perinatal period, can lead to disorders in emotional behaviors at offspring. GLP-1 may play a role in the regulation of anxiety-like behavior in rodents. The aim of this study was to asses if Liraglutide (a GLP-1 receptor agonist; LIR) given to pregnant rats may prevent the deleterious effects of FR in the anxiety-like behavior in pups at 21 days and two months of age males.Twenty-five pregnant Sprague-Dawley r...

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...

Introduction: A positive correlation between serum thyrotropin concentrations (TSH) and body mass index (BMI) has been demonstrated. Some studies not shown this, in euthyroid subjects, or observed only if thyroid autoimmunity (TA) is present or in non-smokers (NS). Leptin (Lp) could be the major link between BMI and TSH.Design: To analyze the relationship between TSH, free thyroxine (FT4), Lp, TA (peroxidase and/or thyroglobulin antibodies) an...

Background: All children with Growth Hormone Deficiency (GHD) should have a Magnetic Resonance Imaging (MRI) scan performed as standard (GH Research Society, 2000).Aims: To determine whether all patients diagnosed with GHD as determined by stimulation testing had an MRI scan performed; and to examine the relationship between the results of endocrine investigations and MRI scans.Methods: Retrospective review of all children who had ...

Introduction: Leptin seems to be a major link between obesity and thyroid dysfunction.Design: To analyze the relationship between thyrotropin (TSH) and leptin (LP) plasma concentrations and body mass index (BMI), in 785 subjects (448 women) of 41.27±9.72 years and BMI 28.91±9.8 (18.04–93.98 kg/m2), without diagnosed thyroid disease or pregnancy, concentrations of TSH, free thyroxine (FT4), LP, glycemia and insulinemia...